Relationship of Obesity and Breast Cancer Mortality

 Obesity appears to increase the risk of breast cancer–related deaths by about one-third in premenopausal but, surprisingly, not postmenopausal women with estrogen receptor–positive disease, investigators report.

An analysis of pooled data on 80,000 patients enrolled in 70 clinical trials showed that among 60,000 patients with estrogen receptor (ER)-positive disease, body mass index (BMI) was associated with risk for breast cancer mortality in both pre- and perimenopausal women.

But after adjustment for patient factors and tumor characteristics, the association remained significant only for premenopausal women with ER-positive tumors, who had a 34% higher risk of dying from breast cancer, said Dr. Hongchao Pan, on behalf of colleagues in the Early Breast Cancer Trialists’ Collaborative Group.

“To our surprise, we found little independent adverse effects of obesity in the 40,000 postmenopausal women with ER-positive disease,” Dr. Pan said at a media briefing highlighting research to be presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago, from May 30 through June 3.

There was also no apparent effect among women of any age with ER-negative tumors.

The findings suggest that the mechanisms by which obesity contributes to breast cancer prognosis are still unclear, Dr. Pan said.

By: NEIL OSTERWEIL, Ob.Gyn. News Digital Network

The study was funded by Cancer Research UK, the Medical Research Council, and the British Heart Foundation. Dr. Pan, Dr. Yu, and Dr. Hudis reported having no relevant financial disclosures.

Copyright © 2014 International Medical News Group, LLC. All rights reserved.

Colbert gives bump to Women’s Health

Stephen Colbert’s show  featured clips from the Women’s Health Research Institute’s recent 60 Minutes segment on sex inclusion in research. More than ever, it is essential to include male and female animals at the research level to ensure that sex is examined as a variable that can lead to different treatments and medications for different genders. The Institute has be advocating for full inclusion in human, animal and cell research!

Watch The Colbert Report clip now!

Collaborative Care Helps OB Patients with Depression

Collaborative depression care adapted to women’s health settings appears to improve depressive and functional outcomes and quality of depression care, according to a report online in the journal Obstetrics and Gynecology. Researchers at the University of Washington randomized 102 women to 12 months of collaborative depression management and 103 women to usual obstetric care at two obstetric care sites. All of the women met criteria for major depression, dysthymia, or both. Participants were age 39 on average, and 56 percent had a diagnosis of posttraumatic stress disorder.

The collaborative care model is team-based care that involves psychiatrists, other clinicians, and depression care managers who meet weekly to review patient progress and provide treatment recommendations. The care manager follows up with patients.

Dr. Katherine Wisner Highlights Sex Differences in Depression

On Monday, May 12, 2014, Dr. Katherine Wisner, Director of the Asher Center for Research and Treatment of Depressive Disorders at Northwestern’s Feinberg School of Medicine, was a featured television guest on WCIU, The U. Dr. Wisner discussed sex differences in mental health (particularly in depression and anxiety). She stated that women are twice as likely to have an episode of depression or anxiety than men. This increased risk for women begins at puberty and can be particularly elevated during menstrual cycles and after childbirth. In fact, 5% of women have very severe mood problems right before their period; this is called premenstrual dysphoric disorder (PMDD), and can cause women to become highly irritable with fluctuating moods. Furthermore, Dr. Wisner stated that 1 out of 7 postpartum women undergo depression, as the hormone fluctuation leaves women very vulnerable to depression.

Dr. Wisner emphasized that it is important for women to seek treatment if they feel that they may be suffering from depression or anxiety, as there are treatments available that do work. No women should have to feel depressed or anxious, and it is therefore important to understand how your body and your mind work together for your overall health. Click here to watch the full WCIU feature with Dr. Katherine Wisner.